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Areas of interest: We are focused on delineating the molecular mechanisms underlying the mutagenic and carcinogenic properties of certain environmental and endogenous carcinogens. These include polycyclic aromatic carcinogens, present in automobile exhaust, tobacco smoke and cooked foods, as well as reactive oxygen species and estrogen derivatives. These can cause reaction with DNA. This damaged DNA may initiate cancer by producing mutations during DNA replication. Our research centers on investigating replication and repair of the damaged DNA using computational approaches. We employ computer modeling, molecular mechanics and dynamics simulations and quantum mechanical calculations for structural and thermodynamic analyses, to connect structure and thermodynamics with biological function.
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PI: Dr. Suse Broyde
(Click to view research interests)
The Broyde Group Members
NYU Biology Department
NYU Chemistry Department
New York University
Courtesy of Dr. Shuang Ding
G*CT* Cross-link
S. Ding, K. Kropachev, Y. Cai, M. Kolbanovskiy, S. Durandina, Z. Liu, V. Shafirovich, S. Broyde and N. Geacintov (2011). Nucleic Acids Res. 2011 Dec 1.
Courtesy of Dr. Lei Jia
Human DNA pol k in complex with B[a]P
(Click to download movie)
L. Jia, N. Geacintov and S. Broyde (2008). Nucleic Acides Res. 46(20):6571-84.
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Courtesy of Dr. Yuqin Cai
Nucleotide Excision Repair of A PAH-Damaged Lesion
Y. Cai, N. E. Geacintov and S. Broyde (2010). J. Nucleic Acids. Special Issue on DNA Damage, Mutagenesis and DNA Repair, vol. 2010.
Courtesy of Dr. Yuqin Cai
PAH-damaged Nucleosome Core Particle
Y. Cai, L.Wang, S. Ding, A. Schwaid, N.E. Geacintov and S. Broyde (2010). Biochemistry, 49(46):9943-45.
Courtesy of Hong Mu
Mobile Phenyl Ring of PhIP Distorts Neighboring Base Pairs
(Click to download movie)
D. Reeves, H. Mu, K. Kropachev, Y. Cai, S. Ding, J. Krzeminsky, A. Kolbanovskiy, J. Bolton, S. Amin, K. El-Bayoumy, S. Broyde and N. Geacintov (2011). Nucleic Acids Res. 39(20): 8752-64.
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