Areas of interest: We are focused on delineating the molecular mechanisms underlying the mutagenic and carcinogenic properties of certain environmental and endogenous carcinogens. These include polycyclic aromatic carcinogens, present in automobile exhaust, tobacco smoke and cooked foods, as well as reactive oxygen species and estrogen derivatives. These can cause reaction with DNA. This damaged DNA may initiate cancer by producing mutations during DNA replication. Our research centers on investigating replication and repair of the damaged DNA using computational approaches. Specifically, we employ computer modeling, molecular mechanics and dynamics simulations to obtain ensembles for structural and thermodynamic analyses, to connect structure and thermodynamics with biological function.

         
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The Broyde Group Members

NYU Biology Department

NYU Chemistry Department

NYU

Last Updated: 02/02/2006 06:47 PM